Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardium

Histone deacetylases (HDACs) play a critical role in modulating cardiac function and ischemic injury. HDAC4 was found to be elevated and activated in response to injury. However, whether HDAC4 mediates cardiac function is currently unknown. In this study, we created myocyte-specific activated HDAC4...

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Bibliographic Details
Published in:J Appl Physiol (1985)
Main Authors: Zhang, Ling X., Du, Jianfeng, Zhao, Yu Tina, Wang, Jianguo, Zhang, Shouyan, Dubielecka, Patrycja M., Wei, Lei, Zhuang, Shougang, Qin, Gangjian, Chin, Y. Eugene, Zhao, Ting C.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737459/
https://ncbi.nlm.nih.gov/pubmed/30284520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00006.2018
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