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Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant
Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), a chloride channel normally expressed at the surface of epithelial cells. The most frequent mutation, resulting in Phe-508 deletion, causes CFTR misfolding and its premat...
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| Yayımlandı: | J Biol Chem |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6737230/ https://ncbi.nlm.nih.gov/pubmed/31324722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008738 |
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