Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1(+/−)/ODC transgenic mice

The study of dominantly heritable cancers has provided insights about tumor development. Gorlin syndrome (GS) is an autosomal dominant disorder wherein affected individuals develop multiple basal cell carcinomas (BCCs) of the skin. We developed a murine model of Ptch1 haploinsufficiency on an ornith...

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Pubblicato in:Sci Rep
Autori principali: Li, Changzhao, Mishra, Bharat, Kashyap, Mahendra, Weng, Zhiping, Andrabi, Shaida A., Mukhtar, Shahid M., Kim, Arianna L., Bickers, David R., Kopelovich, Levy, Athar, Mohammad
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737076/
https://ncbi.nlm.nih.gov/pubmed/31506465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49470-w
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