Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing neurodegeneration. Here, we show that HEK293...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Morozova, Viktoriya, Cohen, Leah S., Makki, Ali El-Hadi, Shur, Alison, Pilar, Guillermo, El Idrissi, Abdeslem, Alonso, Alejandra D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737038/
https://ncbi.nlm.nih.gov/pubmed/31555098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00403
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