Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing neurodegeneration. Here, we show that HEK293...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Morozova, Viktoriya, Cohen, Leah S., Makki, Ali El-Hadi, Shur, Alison, Pilar, Guillermo, El Idrissi, Abdeslem, Alonso, Alejandra D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737038/
https://ncbi.nlm.nih.gov/pubmed/31555098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00403
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