Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing neurodegeneration. Here, we show that HEK293...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Cell Neurosci
Prif Awduron: Morozova, Viktoriya, Cohen, Leah S., Makki, Ali El-Hadi, Shur, Alison, Pilar, Guillermo, El Idrissi, Abdeslem, Alonso, Alejandra D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737038/
https://ncbi.nlm.nih.gov/pubmed/31555098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00403
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