IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

The insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs/IGF2BPs) IMP1 and 3 are regarded as oncofetal proteins, whereas the hepatic IMP2 expression in adults is controversially discussed. The splice variant IMP2-2/p62 promotes steatohepatitis and hepatocellular carcinoma. Aim of this stu...

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Pubblicato in:Front Med (Lausanne)
Autori principali: Czepukojc, Beate, Abuhaliema, Ali, Barghash, Ahmad, Tierling, Sascha, Naß, Norbert, Simon, Yvette, Körbel, Christina, Cadenas, Cristina, van Hul, Noemi, Sachinidis, Agapios, Hengstler, Jan G., Helms, Volkhard, Laschke, Matthias W., Walter, Jörn, Haybaeck, Johannes, Leclercq, Isabelle, Kiemer, Alexandra K., Kessler, Sonja M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737005/
https://ncbi.nlm.nih.gov/pubmed/31555647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2019.00179
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