Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing

OBJECTIVES: The current WHO weight-based dosing recommendations for efavirenz result in a wide variability of drug exposure in children. Our objectives are to characterize the effects of rifampicin- and isoniazid-containing anti-TB therapy and CYP2B6 activity on efavirenz concentrations in children,...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Alghamdi, Wael A, Antwi, Sampson, Enimil, Anthony, Yang, Hongmei, Dompreh, Albert, Wiesner, Lubbe, Langaee, Taimour, Peloquin, Charles A, Kwara, Awewura
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736323/
https://ncbi.nlm.nih.gov/pubmed/31243456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz238
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