Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies

HIV envelope protein (Env) is the sole target of broadly neutralizing antibodies (BNAbs) that are capable of neutralizing diverse strains of HIV. While BNAbs develop spontaneously in a subset of HIV-infected patients, efforts to design an envelope protein-based immunogen to elicit broadly neutralizi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhu, Hong, Mathew, Elizabeth, Connelly, Sara M., Zuber, Jeffrey, Sullivan, Mark, Piepenbrink, Michael S., Kobie, James J., Dumont, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736307/
https://ncbi.nlm.nih.gov/pubmed/31504041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221550
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