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From general base to general acid catalysis in a sodium-specific DNAzyme by a guanine-to-adenine mutation
Recently, a few Na(+)-specific RNA-cleaving DNAzymes were reported, where nucleobases are likely to play critical roles in catalysis. The NaA43 and NaH1 DNAzymes share the same 16-nt Na(+)-binding motif, but differ in one or two nucleotides in a small catalytic loop. Nevertheless, they display an op...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6736077/ https://ncbi.nlm.nih.gov/pubmed/31276580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz578 |
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