SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170

SIRT6 is critical for activating transcription of Nuclear factor (erythroid-derived 2)-like 2 (NRF2) responsive genes during oxidative stress. However, while the mechanism of SIRT6-mediated silencing is well understood, the mechanism of SIRT6-mediated transcriptional activation is unknown. Here, we...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Rezazadeh, Sarallah, Yang, David, Tombline, Gregory, Simon, Matthew, Regan, Sean P, Seluanov, Andrei, Gorbunova, Vera
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736037/
https://ncbi.nlm.nih.gov/pubmed/31216030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz528
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