SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair

When transcribed DNA is damaged, the transcription and DNA repair machineries must interact to ensure successful DNA repair. The mechanisms of this interaction in the context of chromatin are still being elucidated. Here we show that the SIRT6 protein enhances non-homologous end joining (NHEJ) DNA r...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Rezazadeh, Sarallah, Yang, David, Biashad, Seyed Ali, Firsanov, Denis, Takasugi, Masaki, Gilbert, Michael, Tombline, Gregory, Bhanu, Natarajan V., Garcia, Benjamin A., Seluanov, Andrei, Gorbunova, Vera
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343504/
https://ncbi.nlm.nih.gov/pubmed/32584788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103567
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