SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair

When transcribed DNA is damaged, the transcription and DNA repair machineries must interact to ensure successful DNA repair. The mechanisms of this interaction in the context of chromatin are still being elucidated. Here we show that the SIRT6 protein enhances non-homologous end joining (NHEJ) DNA r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging (Albany NY)
Prif Awduron: Rezazadeh, Sarallah, Yang, David, Biashad, Seyed Ali, Firsanov, Denis, Takasugi, Masaki, Gilbert, Michael, Tombline, Gregory, Bhanu, Natarajan V., Garcia, Benjamin A., Seluanov, Andrei, Gorbunova, Vera
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals 2020
Pynciau:
Priority Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343504/
https://ncbi.nlm.nih.gov/pubmed/32584788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103567
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