SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair

When transcribed DNA is damaged, the transcription and DNA repair machineries must interact to ensure successful DNA repair. The mechanisms of this interaction in the context of chromatin are still being elucidated. Here we show that the SIRT6 protein enhances non-homologous end joining (NHEJ) DNA r...

詳細記述

保存先:
書誌詳細
出版年:Aging (Albany NY)
主要な著者: Rezazadeh, Sarallah, Yang, David, Biashad, Seyed Ali, Firsanov, Denis, Takasugi, Masaki, Gilbert, Michael, Tombline, Gregory, Bhanu, Natarajan V., Garcia, Benjamin A., Seluanov, Andrei, Gorbunova, Vera
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals 2020
主題:
Priority Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343504/
https://ncbi.nlm.nih.gov/pubmed/32584788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103567
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