Mice lacking membrane estrogen receptor 1 are protected from reproductive pathologies resulting from developmental estrogen exposure()

Both membrane and nuclear fractions of estrogen receptor 1 (ESR1) mediate 17β-estradiol (E2) actions. Mice expressing nuclear (n)ESR1 but lacking membrane (m)ESR1 (nuclear-only estrogen receptor 1 [NOER] mice) show reduced E2 responsivity and reproductive abnormalities culminating in adult male and...

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Bibliographic Details
Published in:Biol Reprod
Main Authors: Nanjappa, Manjunatha K, Medrano, Theresa I, Mesa, Ana M, Ortega, Madison T, Caldo, Paul D, Mao, Jiude, Kinkade, Jessica A, Levin, Ellis R, Rosenfeld, Cheryl S, Cooke, Paul S
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736026/
https://ncbi.nlm.nih.gov/pubmed/31141131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioz090
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