Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice

Estrogen receptor 1 (ESR1) mediates major reproductive functions of 17β-estradiol (E2). Male Esr1 knockout (Esr1KO) mice are infertile due to efferent ductule and epididymal abnormalities. The majority of ESR1 is nuclear/cytoplasmic; however, a small fraction is palmitoylated at cysteine 451 in mice...

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Publicat a:Endocrinology
Autors principals: Nanjappa, Manjunatha K., Hess, Rex A., Medrano, Theresa I., Locker, Seth H., Levin, Ellis R., Cooke, Paul S.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929544/
https://ncbi.nlm.nih.gov/pubmed/27145009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1085
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