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Inhibition of p53 inhibitors: progress, challenges and perspectives

p53 is the major tumor suppressor and the most frequently inactivated gene in cancer. p53 could be disabled either by mutations or by upstream negative regulators, including, but not limited to MDM2 and MDMX. p53 activity is required for the prevention as well as for the eradication of cancers. Rest...

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Detalhes bibliográficos
Publicado no:J Mol Cell Biol
Main Authors: Sanz, Gema, Singh, Madhurendra, Peuget, Sylvain, Selivanova, Galina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735775/
https://ncbi.nlm.nih.gov/pubmed/31310659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz075
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