Copy number gain of ZEB1 mediates a double-negative feedback loop with miR-33a-5p that regulates EMT and bone metastasis of prostate cancer dependent on TGF-β signaling

Background: The reciprocal repressive loop between ZEB1 and miRNAs has been extensively reported to play an important role in tumor progression and metastasis of various human tumor types. The aim of this study was to elucidate the role and the underlying mechanism of the double-negative feedback lo...

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Bibliografische gegevens
Gepubliceerd in:Theranostics
Hoofdauteurs: Dai, Yuhu, Wu, Zhengquan, Lang, Chuandong, Zhang, Xin, He, Shaofu, Yang, Qing, Guo, Wei, Lai, Yingrong, Du, Hong, Peng, Xinsheng, Ren, Dong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ivyspring International Publisher 2019
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735523/
https://ncbi.nlm.nih.gov/pubmed/31534537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.36735
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