Negative feedback loop between p66(Shc) and ZEB1 regulates fibrotic EMT response in lung cancer cells

The epithelial-to-mesenchymal transition (EMT) program is crucial for the epithelial cancer progression and fibrotic diseases. Our previous work has demonstrated that p66(Shc), a focal adhesion-associated adaptor protein, is frequently downregulated in lung cancers and its depletion promotes metasta...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Li, X, Gao, D, Wang, H, Yang, J, Yan, X, Liu, Z, Ma, Z
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650543/
https://ncbi.nlm.nih.gov/pubmed/25837484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.74
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