miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis

Epithelial tumour cells can gain invasive and metastatic capabilities by undergoing an epithelial–mesenchymal transition. Transcriptional regulators and post-transcriptional effectors like microRNAs orchestrate this process of high cellular plasticity and its malignant consequences. Here, using micr...

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Publicado no:Nat Commun
Main Authors: Diepenbruck, Maren, Tiede, Stefanie, Saxena, Meera, Ivanek, Robert, Kalathur, Ravi Kiran Reddy, Lüönd, Fabiana, Meyer-Schaller, Nathalie, Christofori, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660124/
https://ncbi.nlm.nih.gov/pubmed/29079737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01197-w
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