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Functional Interaction of BRCA1 and CREBBP in Murine Hematopoiesis

Both BRCA1 and CREBBP are tumor suppressor genes that are important for hematopoiesis. We have previously shown that mouse Brca1 is essential for hematopoietic stem cell (HSC) viability. In contrast to Brca1 deficiency, which results in pancytopenia, we report here that Crebbp deficiency results in...

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Publicado en:iScience
Main Authors: Holmstrom, Sam R., Wijayatunge, Ranjula, McCrum, Kelly, Mgbemena, Victoria E., Ross, Theodora S.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734175/
https://ncbi.nlm.nih.gov/pubmed/31499338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.08.031
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