Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans

Continuous laminar shear stress increases the process of autophagy, activates endothelial nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOS(S1177)), and generates NO in bovine and human arterial endothelial cells (ECs) compared with static controls. However, the translational relevan...

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Dettagli Bibliografici
Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Park, Seul-Ki, La Salle, D. Taylor, Cerbie, James, Cho, Jae Min, Bledsoe, Amber, Nelson, Ashley, Morgan, David E., Richardson, Russell S., Shiu, Yan-Ting, Boudina, Sihem, Trinity, Joel D., Symons, J. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
Soggetti:
Rapid Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734082/
https://ncbi.nlm.nih.gov/pubmed/30412436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00561.2018
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