Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3

Epoxyeicosatrienoic acids (EETs) decrease cardiac ischemia-reperfusion injury; however, the mechanism of their protective effect remains elusive. Here, we investigated the cardioprotective action of a novel EET analog, EET-B, in reperfusion and the role of hypoxia-inducible factor (HIF)-1α in such a...

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Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: Neckář, Jan, Hsu, Anna, Hye Khan, Md. Abdul, Gross, Garrett J., Nithipatikom, Kasem, Cyprová, Michaela, Benák, Daniel, Hlaváčková, Markéta, Sotáková-Kašparová, Dita, Falck, John R., Sedmera, David, Kolář, František, Imig, John D.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734065/
https://ncbi.nlm.nih.gov/pubmed/30074840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00726.2017
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