PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis

Children with sepsis and multisystem organ failure have downregulated leukocyte gene expression of peroxisome proliferator-activated receptor-α (PPARα), a nuclear hormone receptor transcription factor that regulates inflammation and lipid metabolism. Mouse models of sepsis have likewise demonstrated...

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Udgivet i:Am J Physiol Heart Circ Physiol
Main Authors: Standage, Stephen W., Bennion, Brock G., Knowles, Taft O., Ledee, Dolena R., Portman, Michael A., McGuire, John K., Liles, W. Conrad, Olson, Aaron K.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734063/
https://ncbi.nlm.nih.gov/pubmed/27881386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00457.2016
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