Non-Hematopoietic PPARα Protects Against Cardiac Injury and Enhances Survival in Experimental Polymicrobial Sepsis

OBJECTIVE: Peroxisome-proliferator activated receptor alpha (PPARα) is significantly downregulated in circulating leukocytes from children with sepsis. PPARα null (Ppara(−/−)) mice have greater mortality than wild type (WT) mice when subjected to sepsis by cecal ligation and puncture (CLP). We sough...

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Detalhes bibliográficos
Publicado no:Crit Care Med
Main Authors: Standage, Stephen W., Waworuntu, Rachel L., Delaney, Martha A., Maskal, Sara M., Bennion, Brock G., Duffield, Jeremy S., Parks, William C., Liles, W. Conrad, McGuire, John K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940302/
https://ncbi.nlm.nih.gov/pubmed/26757163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000001585
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