Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC

Bone-metastatic castration-resistant prostate cancer (CRPC) is lethal due to inherent resistance to androgen deprivation therapy, chemotherapy, and targeted therapies. Despite the fact that a majority of CRPC patients (approximately 70%) harbor a constitutively active PI3K survival pathway, targetin...

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Udgivet i:Am J Clin Exp Urol
Main Authors: Toth, Rachel K, Tran, Jack D, Muldong, Michelle T, Nollet, Eric A, Schulz, Veronique V, Jensen, Corbin C, Hazlehurst, Lori A, Corey, Eva, Durden, Donald, Jamieson, Christina, Miranti, Cindy K, Warfel, Noel A
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734039/
https://ncbi.nlm.nih.gov/pubmed/31511835
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