Androgen Receptor-Induced Integrin α6β1 and Bnip3 Promotes Survival and Resistance to PI3K Inhibitors in Castration-Resistant Prostate Cancer

The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration resistant disease (CRPC) when treated with anti-androgen therapy. In CRPC, AR is often aberrantly activated independent of androgen. Targeting survival pathways...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Nollet, Eric A., Cardo-Vila, Marina, Ganguly, Sourik S., Tran, Jack D., Schulz, Veronique V., Cress, Anne, Corey, Eva, Miranti, Cindy K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395876/
https://ncbi.nlm.nih.gov/pubmed/32565538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1370-9
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