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Genome-scale CRISPR knockout screen identifies TIGAR as a modifier of PARP inhibitor sensitivity
Treatment of cancer with poly (ADP-ribose) polymerase (PARP) inhibitors is currently limited to cells defective in the homologous recombination (HR) pathway. Identification of genetic targets that induce or mimic HR deficiencies will extend the clinical utility of PARP inhibitors. Here we perform a...
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| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6733792/ https://ncbi.nlm.nih.gov/pubmed/31508509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0580-6 |
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