A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer for which treatment options often result in incomplete therapeutic efficacy and long-term side-effects. Interleukin 7 (IL-7) and its receptor IL-7Rα promote T-ALL development and mutational activation of IL-7Rα associa...

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Vydáno v:Leukemia
Hlavní autoři: Akkapeddi, Padma, Fragoso, Rita, Hixon, Julie A., Ramalho, Ana Sofia, Oliveira, Mariana L., Carvalho, Tânia, Gloger, Andreas, Matasci, Mattia, Corzana, Francisco, Durum, Scott K., Neri, Dario, Bernardes, Gonçalo J. L., Barata, João T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733707/
https://ncbi.nlm.nih.gov/pubmed/30850736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0434-8
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