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IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update
Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration a...
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| Publicado no: | Adv Biol Regul |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386770/ https://ncbi.nlm.nih.gov/pubmed/30249539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbior.2018.09.012 |
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