Target-Mediated Disposition Population Pharmacokinetics Model of Erythropoietin in Premature Neonates Following Multiple Intravenous and Subcutaneous Dosing Regimens

Routine erythropoietin (Epo) therapy for neonatal anemia is presently controversial due to its modest response. We speculate that an important contributor to this modest response is that previous clinical study designs were not driven by rigorous mechanistic and kinetic insights into the complex pha...

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Dettagli Bibliografici
Pubblicato in:Eur J Pharm Sci
Autori principali: D’Cunha, Ronilda, Schmidt, Robert, Widness, John A., Mock, Donald M., Yan, Xiaoyu, Cress, Gretchen A., Kuruvilla, Denison, Veng-Pedersen, Peter, An, Guohua
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733583/
https://ncbi.nlm.nih.gov/pubmed/31340188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2019.105013
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