Target-Mediated Disposition Population Pharmacokinetics Model of Erythropoietin in Premature Neonates Following Multiple Intravenous and Subcutaneous Dosing Regimens

Routine erythropoietin (Epo) therapy for neonatal anemia is presently controversial due to its modest response. We speculate that an important contributor to this modest response is that previous clinical study designs were not driven by rigorous mechanistic and kinetic insights into the complex pha...

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Udgivet i:Eur J Pharm Sci
Main Authors: D’Cunha, Ronilda, Schmidt, Robert, Widness, John A., Mock, Donald M., Yan, Xiaoyu, Cress, Gretchen A., Kuruvilla, Denison, Veng-Pedersen, Peter, An, Guohua
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733583/
https://ncbi.nlm.nih.gov/pubmed/31340188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2019.105013
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