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In Vitro Nociceptor Neuroplasticity Associated with In Vivo Opioid-Induced Hyperalgesia

Opioid-induced hyperalgesia (OIH) is a serious adverse event produced by opioid analgesics. Lack of an in vitro model has hindered study of its underlying mechanisms. Recent evidence has implicated a role of nociceptors in OIH. To investigate the cellular and molecular mechanisms of OIH in nocicepto...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Khomula, Eugen V., Araldi, Dioneia, Levine, Jon D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733538/
https://ncbi.nlm.nih.gov/pubmed/31300521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1191-19.2019
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