Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming

In addition to analgesia, opioids produce opioid-induced hyperalgesia (OIH) and neuroplasticity characterized by prolongation of inflammatory-mediator-induced hyperalgesia (hyperalgesic priming). We evaluated the hypothesis that hyperalgesia and priming induced by opioids are mediated by similar noc...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Araldi, Dioneia, Bogen, Oliver, Green, Paul G., Levine, Jon D.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697398/
https://ncbi.nlm.nih.gov/pubmed/31209174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0966-19.2019
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