A head-to-head comparison of conjugation methods for VHHs: Random maleimide-thiol coupling versus controlled click chemistry

Targeted delivery of therapeutics is an attractive strategy for vascular diseases. Recently, variable domains of heavy-chain-only antibodies (VHHs) have gained momentum as targeting ligands to achieve this. Targeting ligands need adequate conjugation to the preferred delivery platform. When choosing...

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Detalhes bibliográficos
Publicado no:Int J Pharm X
Main Authors: van Moorsel, Marc V.A., Urbanus, Rolf T., Verhoef, S., Koekman, C.A., Vink, Maurice, Vermonden, T., Maas, Coen, Pasterkamp, Gerard, Schiffelers, Raymond M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733300/
https://ncbi.nlm.nih.gov/pubmed/31517285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpx.2019.100020
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