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Tunable degradation of maleimide-thiol adducts in reducing environments

Addition chemistries are widely used in preparing biological conjugates, and in particular, maleimide-thiol adducts have been widely employed. Here we show that the resulting succinimide thioether formed by a Michael type addition of a thiol to N-ethylmaleimide (NEM), generally accepted as stable, c...

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Detalhes bibliográficos
Main Authors: Baldwin, Aaron D., Kiick, Kristi L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220410/
https://ncbi.nlm.nih.gov/pubmed/21863904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200148v
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