Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy

Characterising the structural dynamics of proteins and the effects of excipients are critical for optimising the design of formulations. In this work we investigated four lyophilised formulations containing bovine serum albumin (BSA) and three formulations containing a monoclonal antibody (mAb, here...

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Detalhes bibliográficos
Publicado no:Int J Pharm X
Main Authors: Shmool, Talia A., Woodhams, P.J., Leutzsch, Markus, Stephens, Amberley D., Gaimann, Mario U., Mantle, Michael D., Kaminski Schierle, Gabriele S., van der Walle, Christopher F., Zeitler, J. Axel
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733290/
https://ncbi.nlm.nih.gov/pubmed/31517287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpx.2019.100022
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