Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8(+) T cells compared with women with BRCA wild-type disease during the early disease course

Immunosuppressive myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are associated with immunologic tolerance and poor prognosis in ovarian cancer (OvCa). We hypothesized that women with germline BRCA1 and BRCA2 mutation-associated (gBRCAm) OvCa would have fewer circulating imm...

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Veröffentlicht in:Oncol Lett
Hauptverfasser: Lee, Jung-Min, Botesteanu, Dana-Adriana, Tomita, Yusuke, Yuno, Akira, Lee, Min-Jung, Kohn, Elise C., Annunziata, Christina M., Matulonis, Ursula, MacDonald, Lauren A., Nair, Jayakumar R., Macneill, Kimberley M., Trepel, Jane B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2019
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732977/
https://ncbi.nlm.nih.gov/pubmed/31516602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2019.10731
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