Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first in class, proof-of-concept, single arm phase 2 study

BACKGROUND: High-grade serous ovarian carcinoma (HGSOC) is characterized by TP53 mutations, DNA repair defects, and genomic instability. We hypothesized that prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, would be active in BRCA wild-type HGSOC. METHODS: In this open label, single ce...

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Gepubliceerd in:Lancet Oncol
Hoofdauteurs: Lee, Jung-Min, Nair, Jayakumar, Zimmer, Alexandra, Lipkowitz, Stanley, Annunziata, Christina M., Merino, Maria J., Swisher, Elizabeth M., Harrell, Maria I., Trepel, Jane B., Lee, Min-Jung, Bagheri, Mohammad H., Botesteanu, Dana-Adriana, Steinberg, Seth M., Minasian, Lori, Ekwede, Irene, Kohn, Elise C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366122/
https://ncbi.nlm.nih.gov/pubmed/29361470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(18)30009-3
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