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Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease
INTRODUCTION: Study outcomes can be measured repeatedly based on the clinical trial protocol before randomization during what is known as the “run-in” period. However, it has not been established how best to incorporate run-in data into the primary analysis of the trial. METHODS: We proposed two-per...
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| Published in: | Alzheimers Dement (N Y) |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Elsevier
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6732759/ https://ncbi.nlm.nih.gov/pubmed/31517032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2019.07.007 |
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