Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease

INTRODUCTION: Study outcomes can be measured repeatedly based on the clinical trial protocol before randomization during what is known as the “run-in” period. However, it has not been established how best to incorporate run-in data into the primary analysis of the trial. METHODS: We proposed two-per...

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Bibliographic Details
Published in:Alzheimers Dement (N Y)
Main Authors: Wang, Guoqiao, Aschenbrenner, Andrew J., Li, Yan, McDade, Eric, Liu, Lei, Benzinger, Tammie L.S., Bateman, Randall J., Morris, John C., Hassenstab, Jason J., Xiong, Chengjie
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732759/
https://ncbi.nlm.nih.gov/pubmed/31517032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2019.07.007
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