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A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer’s disease

Clinical trial outcomes for Alzheimer’s disease are typically analyzed by using the mixed model for repeated measures (MMRM) or similar models that compare an efficacy scale change from baseline between treatment arms with or without participants’ disease stage as a covariate. The MMRM focuses on a...

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Detalles Bibliográficos
Publicado en:Stat Med
Main Authors: Wang, Guoqiao, Berry, Scott, Xiong, Chengjie, Hassenstab, Jason, Quintana, Melanie, McDade, Eric M., Delmar, Paul, Vestrucci, Matteo, Sethuraman, Gopalan, Bateman, Randall J.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105413/
https://ncbi.nlm.nih.gov/pubmed/29761523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7811
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