The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation

We proposed that circulating metabolites generated by the intestinal microbiota can affect vascular function. One such metabolite, indole 3-propionic acid (IPA), can activate the pregnane X receptor(PXR), a xenobiotic-activated nuclear receptor present in many tissues, including the vascular endothe...

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Pubblicato in:Am J Physiol Endocrinol Metab
Autori principali: Pulakazhi Venu, Vivek Krishna, Saifeddine, Mahmoud, Mihara, Koichiro, Tsai, Yi-Cheng, Nieves, Kristoff, Alston, Laurie, Mani, Sridhar, McCoy, Kathy D., Hollenberg, Morley D., Hirota, Simon A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732469/
https://ncbi.nlm.nih.gov/pubmed/31211619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00572.2018
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