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Lack of antinociceptive cross-tolerance with co-administration of morphine and fentanyl into the periaqueductal gray of male Sprague-Dawley rats

Tolerance to the antinociceptive effect of mu-opioid receptor (MOPr) agonists, such as morphine and fentanyl, greatly limits their effectiveness for long-term use to treat pain. Clinical studies have shown that combination therapy and opioid rotation can be used to enhance opioid-induced antinocicep...

詳細記述

保存先:
書誌詳細
出版年:J Pain
主要な著者: Bobeck, Erin N, Schoo, Shauna M, Ingram, Susan L, Morgan, Michael M
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732057/
https://ncbi.nlm.nih.gov/pubmed/30853505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2019.03.002
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