The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage

The fat mass and obesity-associated gene (FTO) encodes an m6A RNA demethylase that controls mRNA processing and has been linked to both obesity and bone mineral density in humans by genome-wide association studies. To examine the role of FTO in bone, we characterized the phenotype of mice lacking Ft...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhang, Qian, Riddle, Ryan C., Yang, Qian, Rosen, Clifford R., Guttridge, Denis C., Dirckx, Naomi, Faugere, Marie-Claude, Farber, Charles R., Clemens, Thomas L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731662/
https://ncbi.nlm.nih.gov/pubmed/31434789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905489116
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