Thickness of the airway surface liquid layer in the lung is affected in cystic fibrosis by compromised synergistic regulation of the ENaC ion channel

The lung epithelium is lined with a layer of airway surface liquid (ASL) that is crucial for healthy lung function. ASL thickness is controlled by two ion channels: epithelium sodium channel (ENaC) and cystic fibrosis (CF) transmembrane conductance regulator (CFTR). Here, we present a minimal mathem...

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Vydáno v:J R Soc Interface
Hlavní autoři: Olivença, Daniel V., Fonseca, Luis L., Voit, Eberhard O., Pinto, Francisco R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2019
Témata:
Life Sciences–Mathematics interface
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731490/
https://ncbi.nlm.nih.gov/pubmed/31455163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2019.0187
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