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Systemic delivery and SPECT/CT in vivo imaging of (125)I-labelled oncolytic adenoviral mutants in models of pancreatic cancer

Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered intratumorally, resulting in local tumour elimination. Entrapment and binding of adenovirus to erythrocytes, blood factors, and neutralising antibodies hav...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Stella Man, Y. K., Foster, Julie, Carapuça, Elisabete, Davies, James A., Parker, Alan L., Sosabowski, Jane, Halldén, Gunnel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731255/
https://ncbi.nlm.nih.gov/pubmed/31492884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49150-9
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