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Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons

Alzheimer’s disease is a complex disorder encompassing multiple pathological features with associated genetic and molecular culprits. However, target-based therapeutic strategies have so far proved ineffective. The aim of this study is to develop a methodology harnessing the transcriptional changes...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Williams, Gareth, Gatt, Ariana, Clarke, Earl, Corcoran, Jonathan, Doherty, Patrick, Chambers, David, Ballard, Clive
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731247/
https://ncbi.nlm.nih.gov/pubmed/31492831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-019-0555-x
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