ARID1A promotes genomic stability through protecting telomere cohesion

ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (CNAs). Here, we show that ARID1A inactivation causes defects in telomere cohesion, which selectively eliminates gross chromosome aberrations during mitosis. ARID...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Zhao, Bo, Lin, Jianhuang, Rong, Lijie, Wu, Shuai, Deng, Zhong, Fatkhutdinov, Nail, Zundell, Joseph, Fukumoto, Takeshi, Liu, Qin, Kossenkov, Andrew, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Drapkin, Ronny, Lieberman, Paul M., Abate-Shen, Cory T., Zhang, Rugang
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731242/
https://ncbi.nlm.nih.gov/pubmed/31492885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12037-4
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