ARID1A promotes genomic stability through protecting telomere cohesion

ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (CNAs). Here, we show that ARID1A inactivation causes defects in telomere cohesion, which selectively eliminates gross chromosome aberrations during mitosis. ARID...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Zhao, Bo, Lin, Jianhuang, Rong, Lijie, Wu, Shuai, Deng, Zhong, Fatkhutdinov, Nail, Zundell, Joseph, Fukumoto, Takeshi, Liu, Qin, Kossenkov, Andrew, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Drapkin, Ronny, Lieberman, Paul M., Abate-Shen, Cory T., Zhang, Rugang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731242/
https://ncbi.nlm.nih.gov/pubmed/31492885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12037-4
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