Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention

Insulin-degrading enzyme (IDE) is one of the proteins that has been demonstrated to play a key role in degrading β-amyloid (Aβ) monomer in vitro and in vivo, raising the possibility of upregulating IDE as an approach to reduce Aβ. Little is known, however, about the cellular and molecular regulation...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zhao, Lixia, Teter, Bruce, Morihara, Takashi, Lim, Giselle P., Ambegaokar, Surendra S., Ubeda, Oliver J., Frautschy, Sally A., Cole, Greg M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730264/
https://ncbi.nlm.nih.gov/pubmed/15590928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2860-04.2004
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