Evidence of Aβ- and transgene-dependent defects in ERK-CREB signaling in Alzheimer’s models

Extracellular-signal regulated kinase (ERK) signaling is critical for memory and tightly regulated by acute environmental stimuli. In Alzheimer disease transgenic models, active ERK is shown to first be increased, then later reduced, but whether these baseline changes reflect disruptions in ERK sign...

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Huvudupphovsmän: Ma, Qiu-Lan, Harris-White, Marni E., Ubeda, Oliver J., Simmons, Mychica, Beech, Walter, Lim, Giselle P., Teter, Bruce, Frautschy, Sally A., Cole, Greg M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527620/
https://ncbi.nlm.nih.gov/pubmed/17760871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.04869.x
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