Brain Insulin Impairs Amyloid-β(1-40) Clearance from the Brain

Cerebral amyloid-β peptide (Aβ) clearance plays a key role in determining the brain level of Aβ; however, its mechanism remains unclear. In this study, we investigated cerebral Aβ clearance across the blood-brain barrier (BBB) by using the Brain Efflux Index method. [(125)I]Aβ(1-40) was eliminated f...

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Pubblicato in:J Neurosci
Autori principali: Shiiki, Takeshi, Ohtsuki, Sumio, Kurihara, Atsushi, Naganuma, Hideo, Nishimura, Kenji, Tachikawa, Masanori, Hosoya, Ken-ichi, Terasaki, Tetsuya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2004
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730166/
https://ncbi.nlm.nih.gov/pubmed/15509750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2236-04.2004
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