Dysregulated IP(3) Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation in Presenilin1 Results in Exaggerated Ca(2+) Signals and Altered Membrane Excitability

Disruptions in intracellular Ca(2+) signaling are proposed to underlie the pathophysiology of Alzheimer's disease (AD), and it has recently been shown that AD-linked mutations in the presenilin 1 gene (PS1) enhance inositol triphosphate (IP(3))-mediated Ca(2+) liberation in nonexcitable cells....

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Publicat a:J Neurosci
Autors principals: Stutzmann, Grace E., Caccamo, Antonella, LaFerla, Frank M., Parker, Ian
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2004
Matèries:
Neurobiology of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729995/
https://ncbi.nlm.nih.gov/pubmed/14724250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4386-03.2004
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