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Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease
C1q, the recognition component of the classical complement activation pathway, is a multifunctional protein known to be expressed in brain of Alzheimer's disease (AD) patients. To experimentally address the role of C1q in AD, a mouse model lacking C1q (APPQ-/-) was generated by crossing Tg2576...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6729885/ https://ncbi.nlm.nih.gov/pubmed/15269255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0901-04.2004 |
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